N-terminal Trimming Supports Proteostasis Under Secretory Protein Mislocalization Stress
Jasmine P Castellanos, Khanh K Nguyen, Qiqi Lin, Ziqi Lyu, Zi Yang, Fabella Sarwono, Jean Carlo Gonzalez, Walter Nguyen, Lyna T. Huynh, Carolina Canizal, Prasanna Satpute‐Krishnan, Wei Q Shi, Joseph C. Genereux
The paper shows that N-terminal trimming of mislocalized secretory proteins helps maintain proteostasis by reducing aggregation and preventing proteasomal degradation.
bioRxiv · Oct 15, 2026 · PreprintCell Biology