Fadi Nikola

This study identifies a monocyte-macrophage-fibroblast axis in post-COVID-19 lung fibrosis using multi-omic profiling and shows its potential as a therapeutic target.

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

This study examines hypoxia-induced cardiopulmonary remodeling in mice, finding that pulmonary artery stiffening due to collagen remodeling precedes and correlates with cardiac and lung dysfunction, with partial recovery observed after normoxia.

This study investigates GPR87's role in pulmonary fibrosis, finding it highly expressed in IPF lungs and protective against fibrosis when knocked down in multiple models.