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Satellite cell glucocorticoid receptor restrains myogenic commitment without mediating the effects of therapeutic glucocorticoids on muscle repair

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

Residual Hearing Loss After Chronic Cochlear Implantation in Guinea Pigs is Primarily Conductive

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

Ribosomal Remodeling and Translational Suppression in the Post-Arrest Heart

This study investigates how cardiac arrest affects myocardial ribosome biology and protein synthesis in pigs and mice, finding increased ribosomal transcripts with ischemic burden and suppressed ribosome activity post-arrest.

Isocaloric restriction of a high-fat diet under TAK-242 administration: metabolic and gut microbial responses in mice

This study examines the effects of isocaloric high-fat diet restriction with TAK-242 on metabolic and gut microbial responses in mice, finding limited normalization of adiposity and microbial community.

Epigenetic Rescue of Disuse Muscle Atrophy by Histone Deacetylase Inhibitor Trichostatin A

This study shows that Trichostatin A, an HDAC inhibitor, reduces muscle atrophy and preserves nuclear organization in mice subjected to mechanical unloading.

Responses of Muscle Volume, Strength, and Motor Unit Properties to Bed Rest and Retraining in Young Males and Females

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

High latitude, high tolerance: Northern juvenile Chinook salmon exhibit substantial thermal plasticity and acute heat tolerance

This study shows that northern juvenile Chinook salmon have high thermal tolerance and plasticity, with warm acclimation improving heat tolerance and cardiac function.

Functional Assessment and Extended Culture of Human Pediatric Cardiac Tissue Slices for Preclinical Testing

This study develops a method to culture human pediatric cardiac tissue slices for extended periods, enabling functional and pharmacological testing of cardiac physiology.

Site-, strain- and mutation-specific osteopetrosis phenotypes in mice with Clcn7 variants

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

A microstructural analysis of water intake patterns associated with light phase food and water restriction in male and female rats.

The paper examines how food and water intake patterns in rats change under light phase restrictions, finding that food access timing more strongly influences water intake than water access timing influences food intake.

Nutrient-responsive midgut turnover is spatially controlled by serotonin signaling

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

mTORC1-dependent control of Hedgehog signaling mediates nutrient-responsive licensing of intestinal stem cell differentiation

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

A transient pulse of neuronal ATF4 installs a durable non-autonomous programme promoting healthy ageing

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

Partial agonists and heteromeric Kainate receptor desensitization

This study investigates how partial agonists affect desensitization in KARs, showing that agonist residence time and LBD closure are more critical than subunit composition in heteromeric receptors.

Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression

This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.

Latent Transforming Growth Factor Binding Protein-2 promotes microfibrillar TGF-β bioavailability to drive pathologic fibrosis in remote regions of infarcted hearts

This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.

An LRH-1 agonist reverses hepatic metabolic dysfunction in obesity

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

Circadian feeding rhythm loss drives sex-specific β-cell dysfunction in diet-induced obesity

This study shows that diet-induced obesity disrupts circadian β-cell function more in male mice than females, with time-restricted feeding partially restoring these effects.

Age-related biological dysregulation quantified using metabolomics is composed of distinct subsystems with synergistic associations to health outcomes: An analysis of the Canadian Longitudinal Study on Aging

The paper quantifies age-related biological dysregulation using metabolomics in older adults and shows it has distinct subsystems linked to health outcomes and DNA methylation.

SCN- induces prestin contraction through reduced intermonomer angles and a modified transporter like movement of each monomer.

The paper investigates how SCN- induces prestin contraction through structural changes in its dimers and monomers, associated with altered intermonomer angles and beta sheet loss.