Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation
Md Mohosin Rana, Andrea L. Cottingham, Sara Kolhatkar, Fanny Xu, Alireza Hassani Najafabadi, Ryan M. Pearson
This study creates mesaconate-based polyester nanoparticles that show different immunomodulatory effects in macrophages and improve survival in endotoxemia.
bioRxiv · Oct 23, 2026 · PreprintBioengineering