Single-Cell RNA Sequencing Reveals Distinct Cellular and Molecular Features of Steroid-Induced Osteonecrosis of the Femoral Head Compared to Alcohol-Induced Osteonecrosis and Hip Osteoarthritis
Arijita Sarkar, Matthew C Gallo, Jennifer A Bell, Cory K Mayfield, Jacob R Ball, Fergui Hernandez, Elizabeth Lechtholz-Zey, Tara Shelby, Osamu Sugiyama, Denis Evseenko, Jay R Lieberman
This study uses single-cell RNA sequencing to compare cellular and molecular features of steroid-induced and alcohol-induced osteonecrosis of the femoral head with hip osteoarthritis, identifying distinct immune and stromal cell signatures.
bioRxiv · Nov 4, 2026 · PreprintGenomics