TGF-b/TIF1g signaling restrains CD8+ T cell expansion while preserving cytotoxic competence
Jesus Daniel Zambrano-Romero, Eugenio Contreras-Castillo, Veronica Yutsil Garcia-Rasilla, Ma Cleofas Marcial-Medina, Diana Berenice Rios-Ramirez, Jose Luis Ramos-Balderas, Javier Orozco-Cordoba, Luis Tenorio-Hernandez, Alfredo Ibarra-Sanchez, Diego Delgado-Saldivar, Harumichi Ishigame, Maria Carolina Amezcua-Vesely, Claudia Gonzalez-Espinosa, Florencia Rosetti, Jose C. Crispin, , Paula Licona Limon
This study identifies TIF1g as a regulator of TGF-b signaling in CD8+ T cells, showing it restricts expansion while preserving cytotoxic function.
bioRxiv · Nov 6, 2026 · PreprintImmunology