PANK2-mediated de novo CoA synthesis is required for metabolic switching to fatty acid oxidation
Sandra M. Nordlie, Robert Schafer, Adam J. Rauckhorst, Ana M Santos-Exposito, Andrés Prieto-Rodríguez, Bryce A. Wilson, Idil A. Evans, Una Hadziamehtovic, Frances Nowlen, Carlos Santos‐Ocaña, Eric B. Taylor, Michael C. Kruer, Sergio Padilla-Lopez
The paper shows PANK2 enables CoA synthesis during fatty acid oxidation by overcoming feedback inhibition, supporting its role in metabolic switching.
bioRxiv · Oct 7, 2025 · PreprintBiochemistry