Bayesian Estimation of 3D Chromosomal Structure from Single Cell Hi-C Data
Michael Rosenthal, Darshan Bryner, Fred Huffer, Shane A. Evans, Anuj Srivastava, Nicola Neretti
The paper develops a Bayesian method to infer 3D chromosomal structures from single-cell Hi-C data, incorporating bulk Hi-C as a prior to improve accuracy.
bioRxiv · May 7, 2018 · PreprintBioinformatics