Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1 and 2 in HCT116 colorectal cancer cells
L. Garcia Delgado, A. Derome, S. Longpre, M. Giroux-Dansereau, G. Basbous, C. L. Lavoie, C. Saucier, J.-B. Denault
This study shows that SNX1 and SNX2 regulate MET trafficking, affecting phosphorylation of MET and AKT but not ERK1/2, and influence apoptosis resistance in CRC cells.
bioRxiv · Feb 10, 2024Cancer Biology