Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity
N. Andina, L. de Meuron, A. S. Schnegg-Kaufmann, C. Ansermet, G. Bomaci, N. Keller, N. A. Porret, A. Angelillo-Scherrer, N. Bonadies, R. Allam
This study shows that aging increases NLRP3 inflammasome sensitivity in monocytes, linking it to inflammation and CMML disease severity.
bioRxiv · Jan 27, 2022 · PreprintImmunology