ediTONSIL: Activation-Neutral Gene Editing of CD4 T cells in Human ex Vivo Tonsil Cultures
K. Morath, L. Sadhu, G. Dyckhoff, M. Gapp, O. T. Keppler, O. T. Fackler
The paper introduces ediTONSIL, a method to edit resting CD4 T cells from human tonsil tissue without activation, achieving >90% knockout efficacy and preserving cell function.
bioRxiv · Aug 21, 2023 · PreprintImmunology