G. Irlam

The creation-mutation-selection model: simulation and the advantage of sex

The paper simulates the fitness of asexual and sexual populations using the creation-mutation-selection model and finds that asexuality incurs a larger cost than sex for eukaryotes.

Evidence of macroevolutionary selection of the mutation rate in sexual species

The paper evaluates whether macroevolutionary processes shape germline mutation rates toward population-optimal values by comparing empirical mutation rates with model predictions.

The latent load and the population-optimal mutation rate

The paper presents a framework analyzing genetic load from positively selected sites and estimates the population-optimal mutation rate.