Reprogramming M2-polarized patient-derived glioblastoma associated microglia/macrophages via CSF1R inhibition
V. Fermi, R. Warta, C. Rapp, M. Knoll, G. Jungwirth, C. Jungk, P. Dao Trong, A. von Deimling, A. Abdollahi, A. Unterberg, C. Herold-Mende
This study shows that GW2580 reprograms M2-like glioblastoma-associated macrophages to M1-like cells, enhancing phagocytosis and T-cell killing, and reduces tumor cell proliferation in patient-derived organoids.
bioRxiv · Oct 20, 2022 · PreprintCancer Biology