Dissecting HIV Virulence: Heritability Of Setpoint Viral Load, CD4+ T Cell Decline And Per-Parasite Pathogenicity
F. Bertels, A. Marzel, G. Leventhal, V. Mitov, J. Fellay, H. F. Gunthard, J. Boni, S. Yerly, T. Klimkait, V. Aubert, M. Battegay, A. Rauch, M. Cavassini, A. Calmy, E. Bernasconi, , Swiss HIV Cohort Study
The paper estimates heritability of HIV virulence traits using donor-recipient regression and phylogenetic models, finding moderate heritability for CD4+ T cell decline and per-parasite pathogenicity.
bioRxiv · Sep 8, 2017Evolutionary Biology