HOTAIR promotes an epithelial-to-mesenchymal transition through relocation of the histone demethylase Lsd1
J. Jarroux, C. Bertrand, G. Marc, D. Foretek, Z. Saci, J. A. Londono Vallejo, M. Pinskaya, A. Morillon
This study shows HOTAIR promotes epithelial-to-mesenchymal transition by relocating Lsd1, reprogramming the transcriptome and highlighting Lsd1's role in maintaining epithelial identity.
bioRxiv · Aug 5, 2019 · PreprintCancer Biology