Recovering biological structure in sparse single-cell proteomics with GIRAFI
Huan Zhong, Shuxin Chi, Rachel Wong, Jason C. Rogalski, Ziming Wang, Susanna Y. Chan, Melanie L. Bailey, Arpa Ebrahimi, Gabrielle Jayme, Jerry Yin, Albie Gong, Terrance P. Snutch, Claudia S. Maier, Marco A. Marra, Leonard J. Foster, Xin Tang
GIRAFI improves sparse single-cell proteomics by imputing missing values and revealing cell states using graph-informed statistical learning, outperforming existing methods and recovering biological structure.
bioRxiv · May 21, 2026 · PreprintBioinformatics