Parallel evolution under constraint shapes echinocandin resistance in Candida auris
Nicholas C. Cauldron, Erika N. Dort, Garrett Weeks, Phillip David Rogers, Christina A. Cuomo
Across 681 matched isolates and 22,388 genomes, high-level micafungin resistance in Candida auris arises through recurrent FKS1 hotspot mutations amid strong purifying selection, and FKS2 appears dispensable.
bioRxiv · Sep 3, 2026 · PreprintGenetics✦ In-depth digest