Functional Deorphanization of Tumor-reactive TCRs Uncovers a Landscape of Shared, Immune Dominant Antigens across Cancers
Orian Bricard, Razgar Seyed Rahmani, Frederik Peeters, Chloe Lorent, Thomas Van Brussel, Jieyi Xiong, Evy Vanderheyden, Rogier Schepers, Gino Philips, Eva Lion, Jiska van der Reest, Georg A. Halder, Ann Smeets, Michael Platten, Edward W. Green, , Diether Lambrechts
This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.
bioRxiv · Oct 5, 2026 · PreprintCancer Biology