Extracellular chaperones modulate AL light chains fibrillar aggregation and contribute to amyloid structural heterogeneity
Loredana Marchese, Mariagrazia Battaglia, Palma Patrizia Mangione, Annalisa Relini, Giulia Codroico, Sara Raimondi, Federico Forneris, Silvia Faravelli, Beatrice Leonardini, Claudio Canale, Guglielmo Verona, Diana Canetti, Vittorio Bellotti, Sofia Giorgetti, Alessandra Corazza, Francesca Lavatelli
This study shows that extracellular chaperones like apoE3 and CLU modulate amyloid light chain aggregation and fibril structure, affecting disease pathophysiology and structural variability.
bioRxiv · Jun 2, 2026 · PreprintBiochemistry