CDK4 inactivation balances resistance to apoptosis with heightened metabolic sensitivity in triple negative breast cancer cells
Dorian V. Ziegler, Kanishka Parashar, Lucía C. Leal-Esteban, Jaime López‐Alcalá, Wilson Castro, Nadège Zanou, Laia Martínez-Carreres, Katharina Huber, Xavier Pascal Berney, Marı́a M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Héctor Gallart‐Ayala, , Lluís Fajas
This study shows CDK4 inhibition in TNBC cells reduces apoptosis sensitivity and disrupts mitochondrial calcium signaling through MERCs, contributing to resistance to CDK4/6 inhibitors.
Nature Communications · Jan 9, 2025Peer-reviewedCancer Biology