Inferring modularity in genotype-phenotype maps using patterns of epistasis and pleiotropy
Nicholas Lawson, Grace Brophy, Caroline M. Holmes, Anna Seigal, Michael M. Desai, Samantha Petti
This paper introduces two methods, SLED and GTD, to infer modular structure in genotype-phenotype maps by combining epistasis and pleiotropy, showing they yield similar modular architectures in yeast data.
bioRxiv · Nov 4, 2026 · PreprintEvolutionary Biology