A Distinct Mode of Chromosome-End Genome Instability Revealed by Circulome Characterization and Analyses
Grant Roy, Zhixiang Lei, Matthew McCoy, Aysha Al Sardar, Jerry Shay, Peter Scacheri, Yair Lotan, Stephen D Levene, Andrew Fire, Massa Shoura
This paper identifies a new mode of chromosome-end instability in cancer using circular DNA analysis, revealing a distinct spatial signature called EDGE.
bioRxiv · Nov 4, 2026 · PreprintGenomics