Fatty acid-mediated induction of CYP2E1 activity in HepaRG cells is not systematically associated with exacerbated acetaminophen cytotoxicity
Clémence Penhoat, Julie Massart, Gregory Pinon, Daniel Catheline, Vincent Rioux, Bernard Fromenty, Karima Begriche
This study shows that increased CYP2E1 activity from fatty acids in HepaRG cells does not always lead to greater acetaminophen toxicity, as only certain fatty acids exacerbate liver damage.
bioRxiv · Nov 1, 2024 · PreprintPharmacology & Toxicology