Sampling the conformational space of the catalytic subunit of human γ-secretase
Xiao-chen Bai, Eeson Rajendra, Guanghui Yang, Yigong Shi, Sjors Scheres
The paper uses image classification to identify three conformations of the γ-secretase catalytic subunit, revealing a new transmembrane helix and structural changes upon inhibitor binding.
bioRxiv · Sep 1, 2015Molecular Biology