NeuroscienceImmunityPeer-reviewed
Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease
Andy Po‐Yi Tsai, Chuanpeng Dong, Peter Bor‐Chian Lin…·Gary E. Landreth
The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.
71 citationstop 2%