Structural Basis for the Activation of Proteinase-Activated Receptors (PARs) by Endogenous Ligands
Zongyang Lyu, Xiaoxuan Lyu, Andrey G. Malyutin, Guliang Xia, Daniel W. Carney, Vinícius M. Alves, Matthew S. Falk, Nidhi Arora, Hua Zou, Aaron P. McGrath, Yanyong Kang
This study presents structural insights into PAR1 and PAR2 activation by endogenous ligands, revealing a novel mechanism and potential targets for therapeutic development.
Nature Communications · Apr 26, 2025Peer-reviewedBiochemistry