Author

Guo Chen

Rockefeller University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Aakash DavasamiD· 1 shared Assaf AloniD· 1 shared Baoliang Zhu· 1 shared Bo Wang· 1 shared Brandon Lam· 1 shared Chao YangiD· 1 shared Claire Bryant· 1 shared Dian J. CaoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aakash DavasamORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AlphaFold3 for Structure-guided Ligand Discovery

Kartikeya M. Menon, Aakash Davasam, Guo Chen, Claire Bryant, Zifang Deng, Brandon Lam, Chao Yang, Dylan Barcelos, Fangyu Liu, Assaf Alon, Jiankun Lyu

Retrospective and prospective benchmarks show AlphaFold3 co-folding memorizes training poses and achieves half the prospective hit rate of DOCK3 at 6,700-fold higher cost, but excels as a post-docking filter.

bioRxiv · Jun 12, 2026 · PreprintPharmacology & Toxicology✦ In-depth digest

Macrophage SLC9A1 Links Endocytic Trafficking to Innate Immune Activation in Myocardial Injury

Jinhua Wen, Pablo Parra, Yoshiharu Muto, Guo Chen, MariaSanta C. Mangione, Xiang Luo, Dian J. Cao

This study identifies SLC9A1 as a mediator linking macrophage endocytic trafficking to innate immune activation in myocardial injury, showing its role in inflammation and cardiac remodeling.

bioRxiv · Mar 10, 2026 · PreprintImmunology

Multimodal AI for Single cfDNA Profiling and Cancer Screening

Bo Wang, Liyang Song, Hefei Li, Nan Lin, Ying Xin, Xiaowen He, Wenxin Liu, Li Liu, Jian Cui, Xuesong Li, Ying Mei, Qiuting You, Haodong Zhu, Guoqiang Zhao, Guo Chen, , Yingjiang Ye

The paper develops a Transformer-based model called cfAI to profile and detect cancer-derived cfDNA by integrating methylation, fragmentomics, and histone modifications, achieving high sensitivity and specificity in multi-cancer detection.

bioRxiv · Dec 30, 2025 · PreprintBioinformatics