Aberrant cohesin function in Saccharomyces cerevisiae activates Mcd1 degradation to promote cell lethality
Gurvir Singh, Robert V. Skibbens
The paper shows that aberrant cohesin function in yeast leads to Mcd1 degradation via E3 ligases, promoting cell lethality through a negative feedback mechanism.
PLoS Genetics · Dec 10, 2025Peer-reviewedCell Biology