Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis
Avital Oknin-Vaisman, Deepanjan Panda, Rostislav Novak, Ghazal Kheshaiboun, Eliya Bitman-Lotan, Satish Gandhesiri, Rubina S. Kazi, Nikolett Pahor, Viktoria von Heyl zu Herrnsheim, Yamen Abu Ahmad, Guy Kamnesky, Thorsten Mosler, Markus E. Diefenbacher, Ashraf Brik, Amir Orian
This paper develops R4VPs, PROTAC-like compounds that induce ferroptosis in aggressive cancers while sparing normal cells, showing efficacy against therapy-resistant melanoma and sarcomas.
Oncogene · Jun 5, 2026Peer-reviewedCancer Biology