Bacteroidales Secreted Antimicrobial Protein-1 receptor recognition is coupled to protease-activation to form bactericidal pores.
Shannon N. Mostyn, K Flores, George Hedger, H Nagaraj, Sarah L. Rouse, Laurie E. Comstock, Doryen Bubeck
This study defines the mechanism of BSAP-1 toxin action, showing receptor recognition and protease-activation lead to pore formation in target cells.
bioRxiv · Aug 5, 2026 · PreprintMicrobiology