Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
L. J. Finney, N. Glanville, H. Farne, J. Aniscenko, P. Fenwick, S. Kemp, M.-B. Trujillo-Torralbo, M. Calderazzo, J. A. Wedzicha, P. Mallia, N. W. Bartlett, S. L. Johnston, A. Singanayagam
This study shows inhaled corticosteroids reduce ACE2 expression in COPD, potentially lowering SARS-CoV-2 susceptibility by suppressing type I interferon.
bioRxiv · Jun 13, 2020Immunology