In vitro and in vivo immunogenicity assessment of protein aggregate characteristics
C. Thorlaksen, H. S. Schultz, S. K. Gammelgaard, W. Jiskoot, N. S. Hatzakis, F. S. Nielsen, H. Solberg, V. Fodera, C. Bartholdy, M. Groenning
This study assesses the immunogenicity of human insulin aggregates with varying size, structure, and modifications, finding that flexible aggregates with altered secondary structure are most immunogenic.
bioRxiv · Jul 6, 2022Immunology