Tumor suppressor Hypermethylated in Cancer 1 represses expression of cell cycle regulator E2F7 in human primary cells
L. Lanikova, J. Svec, L. Janeckova, V. Pospichalova, N. Dibus, M. Vojtechova, D. Hrckulak, E. Sloncova, H. Strnad, V. Korinek
This study shows that HIC1 represses E2F7, leading to altered cell cycle progression and DNA repair in CRC, with E2F7 levels linked to patient prognosis.
bioRxiv · Jul 25, 2022 · PreprintCancer Biology