Cancer BiologybioRxiv
Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma
R. Yoshitake, K. Saeki, S. Eto…·T. Nakagawa
This study shows that BRAF mutation activates the RAF/MEK/ERK pathway, leading to COX2 overexpression and PGE2 production in canine urothelial carcinoma, promoting inflammation.
DOI 10.1038/s41598-020-64832-5