K. Saeki

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs

This study shows IRF8 regulates enhancer landscapes and transcriptional programs in postnatal microglia, affecting their identity and response to disease.

Acvr1b loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin

This study shows that Acvr1b loss in combination with Kras mutation promotes precancerous lesions from both acinar and ductal cells in the pancreas, but the IPMN-like phenotype differs when mutations occur in all cells.

Identification and characterization of a proliferative cell population in estrogen receptor-positive metastatic breast cancer through spatial and single-cell transcriptomics

The paper identifies a proliferative cell population in ER+ metastatic breast cancer using spatial and single-cell transcriptomics, showing its role in estrogen-dependent growth and clinical outcomes.

Inactivation of SARS-CoV-2 and influenza A virus by spraying hypochlorous acid solution and hydrogen peroxide solution in the form of Dry Fog

This study evaluates the effectiveness of dry fog disinfectants in inactivating SARS-CoV-2 and influenza A virus on surfaces.

Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma

This study shows that BRAF mutation activates the RAF/MEK/ERK pathway, leading to COX2 overexpression and PGE2 production in canine urothelial carcinoma, promoting inflammation.

miR-10b Deficiency Affords Atherosclerosis Resistance

This study identifies miR-10b as a key mediator in RGS5-dependent endothelial cell degeneration, showing miR-10b deficiency protects against atherosclerosis in mice.