H. Uecker

The many dimensions of combination therapy: How to combine antibiotics to limit resistance evolution

This study evaluates combination antibiotic therapy to limit resistance evolution by analyzing drug interactions and optimal dosing strategies using a stochastic pharmacodynamic model.

Is the distribution of plasmid lengths bimodal?

The paper shows that plasmid length distributions are often misinterpreted due to logarithmic scaling, revealing that log-length distributions can be bimodal while length distributions are unimodal across all plasmids.

Segregational drift hinders the evolution of antibiotic resistance on polyploid replicons

This study shows that polyploid replicons hinder the evolution of antibiotic resistance due to segregational drift, affecting allele establishment probabilities.

Limits to evolutionary rescue by conjugative plasmids

The paper analyzes how conjugative plasmids affect evolutionary rescue in bacterial populations, finding that higher transfer rates can sometimes hinder adaptation due to plasmid competition.

Sequential antibiotic therapy in the lab and in the patient

This study compares antibiotic cycling strategies in lab and patient models, finding that rapid cycling is effective in the lab but slower cycling may be better in patients due to pharmacokinetic factors and drug interactions.

Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids

This study develops a population genetics model for polyploid prokaryotes, showing that beneficial mutations can fix phenotypically before genotypically, creating a heterozygosity window.

The effect of habitat choice on evolutionary rescue in subdivided populations

This study models how habitat choice affects evolutionary rescue in subdivided populations, finding that dispersal rates and immigration biases influence rescue probability in three distinct phases.

Evolutionary rescue and drug resistance on multicopy plasmids

The paper models how bacteria adapt to harsh environments using multicopy plasmids, finding that optimal copy numbers depend on environmental factors and plasmid dominance.

Antibiotic treatment protocols revisited: The challenges of a conclusive assessment by mathematical modeling

This paper reviews mathematical models of antibiotic treatment protocols and highlights methodological challenges in assessing combination therapy, mixing, and cycling.

Evolutionary rescue in randomly mating, selfing, and clonal populations

This study examines how different reproductive strategies affect evolutionary rescue in populations facing environmental change, finding that mating systems influence survival probabilities based on mutation dominance and population dynamics.