Author

Hailey Bruzzone

University of Wisconsin–Madison

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Evolutionary Biology· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Research Focus:sequence-to-function modeling· 1 Approach:variational autoencoder· 1

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Claudia Solís‐LemusiD· 1 shared Evan GorsteiniD· 1 shared Mengze Tang· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperEvolutionary Biology

Claudia Solís‐LemusORCID

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Recent·Most cited

Ancestral Sequences Cannot be Accurately Reconstructed via Interpolation in a Variational Autoencoder's Latent Space

Evan Gorstein, Mengze Tang, Hailey Bruzzone, Claudia Solís‐Lemus

This study tests using a variational autoencoder to reconstruct ancestral sequences by interpolating in its latent space, finding it less accurate than standard methods despite containing evolutionary signal.

Bulletin of Mathematical Biology · Sep 19, 2026Peer-reviewedEvolutionary Biology