A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease across a diverse cohort
Natalie Telis, Hang Dai, Ashley Arana Waring, David Kann, Dana Wyman, Simon J. White, Basil Khuder, Francisco Tanudjaja, Alexandre Bolze, Matthew E. Levy, Cassie Hajek, Lisa M. McEwen, Douglas A. Stoller, Christopher N. Chapman, C. Anwar A. Chahal, , Kelly M. Schiabor Barrett
This paper develops a method to predict Lp(a) levels from genomic data, combining SNV risk scores and KIV-2 repeat counts, and shows it improves risk prediction for cardiovascular disease in diverse populations.
medRxiv · Nov 1, 2024 · PreprintGenetic & Genomic Medicine