wspA mutation mediated Pseudomonas aeruginosa rugose small colony variant and its hyper-biofilm
Qìng Yu, Yue Li, Peiqi Wang, Chen Zhang, Hanming Ni, Yisha Zhang, Yushan Cui, Mengyu Zhou, Jun Ni, Linyue Zhang, Xiaoting Hua, Yunsong Yu, Qiucheng Shi, Xiaoxing Du
This study identifies a wspA mutation in Pseudomonas aeruginosa that increases c-di-GMP synthesis, leading to rugose small colony variant formation and enhanced biofilm-mediated antibiotic resistance.
bioRxiv · Sep 15, 2025 · PreprintMicrobiology