TCR-pMHC bond length controls TCR ligand discrimination
Dibyendu K. Sasmal, Wei Feng, Sobhan Roy, Peter Leung, Yanran He, Chufan Cai, Guoshuai Cao, Huada Lian, Jian Qin, Enfu Hui, Hans Schreiber, Erin Adams, Jun Huang
This study shows that TCR-pMHC bond length controls TCR ligand discrimination by affecting CD3ζ ITAM phosphorylation and downstream signaling.
bioRxiv · Oct 12, 2018 · PreprintImmunology