ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing
Jason Tse, William R. Brothers, Rachel E. Hayward, Sabrina Barbas, Kai Sheng, Kathryn R. Spencer, Kristen E. DeMeester, Evert Njomen, James R. Williamson, David R. Liu, Bruno N. Melillo, Gene Wei-Ming Yeo, Benjamin F. Cravatt, Haoxin Li
ESCAPE identifies covalent ligand-protein interactions by using prime editing to disrupt cysteine residues and assesses their impact on cellular phenotypes.
bioRxiv · Jul 29, 2026 · PreprintBiochemistry