Disruption of cAMP Signalling and RNA Regulation Confers Cefiderocol Resistance in Acinetobacter baumannii
David M. P. De Oliveira, Ruby Heaton, Hayden Whyte, Larissa Buedenbender, Anuk Indraratna, Nhu Thi Khanh Nguyen, Minh-Duy Phan, Saleh F. Alquethamy, Yujiro Hirose, Budi Permana, Amy Wright, Anton Y. Peleg, Micaela Nochomovitz, P. Harris, Kay A. Ramsay, , Brian M. Forde
This study identifies two mechanisms of cefiderocol resistance in Acinetobacter baumannii: cAMP signalling disruption and Hfq RNA-binding domain truncation, both linked to iron homeostasis and reduced drug activity.
bioRxiv · Oct 23, 2026 · PreprintMicrobiology