Endocrine therapy-specific lineage and partial epithelial-mesenchymal reprogramming defines divergent resistant cell-states in ER+ breast cancer
Sarthak Sahoo, Sejal Khanna, Swayamshree Senapati, Hemant Kumar, Jyothi S. Prabhu, Dimple Notani, Sridhar S. Hannenhalli, Mohit Kumar Jolly
This study identifies drug-specific resistance mechanisms in ER+ breast cancer by analyzing multi-omic data, revealing distinct transcriptional and chromatin states associated with SERM, SERD, and ESR1 mutant resistance.
bioRxiv · May 13, 2026 · PreprintCancer Biology