Synthetic BiologybioRxivPreprint
Split RNA switch: Programmable and precise control of gene expression by ensemble of pre- and post-translational regulation
Itsuki Abe, Hirohisa Ohno, Megumi Mochizuki…·Hirohide Saito
The paper introduces split RNA switches that enhance gene regulation specificity by integrating multiple RNA switches through protein splicing, improving ON/OFF ratios and enabling multi-input synthetic circuits.