Author

Hiroko Shimada

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anand SwaroopiD· 2 shared Holly Y. CheniD· 2 shared Kunio NagashimaiD· 2 shared Natalia de ValiD· 2 shared Akihiko Osaki· 1 shared Akihiro FujimotoiD· 1 shared Anupam Kumar MondaliD· 1 shared Asami Nukui· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Anand SwaroopORCID

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Author profile →

3 papers

Recent·Most cited

FOXM1 Expression in Invasive Ductal Breast Carcinoma of No Special Type: Insights from RNA-seq and Immunohistochemical Analysis

Masahiro Ohara, Emi Mikami, Wakako Inohana, Taeko Kurosawa, Ayako Nakame, Ayaka Sakakibara, Yuki Ichinose, Akihiro Fujimoto, Asami Nukui, Aya Asano, Hiroko Shimada, Kyoko Asai, Masataka Hirasaki, Hideki Yokogawa, Kazuo Matsuura, , Toshiaki Saeki

This study investigates FOXM1 expression in invasive ductal breast carcinoma of no special type using RNA-seq and IHC, finding it correlates with poor prognosis and tumor progression.

bioRxiv · Sep 7, 2025 · PreprintCancer Biology

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

Holly Y. Chen, Manju Swaroop, Samantha Papal, Anupam Kumar Mondal, Hyun Beom Song, Laura Campello, Gregory J. Tawa, Florian Régent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G. Jacobson, Wei Zheng, Anand Swaroop

This study identifies reserpine as a drug candidate that improves photoreceptor survival in retinal ciliopathies by restoring proteostasis and ciliogenesis.

eLife · Mar 28, 2023Peer-reviewedGenetic & Genomic Medicine

Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal

Koray Dogan Kaya, Holly Y. Chen, Matthew J. Brooks, Ryan A. Kelley, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Charles T. Drinnan, Linn M. Gieser, Kamil Kruczek, Slaven Erceg, Tiansen Li, Dunja Lukovic, Yogita K. Adlakha, Emily Welby, Anand Swaroop

Comparing retinal organoid transcriptomes against human fetal and adult retina places each culture on a developmental scale; replacing all-trans retinoic acid with 9-cis retinal sped rod differentiation.

bioRxiv · Aug 12, 2019 · PreprintDevelopmental Biology