Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity
Wei-Chun Chang, Hsiao-Ching Wang, Wei-Chung Cheng, Juan-Cheng Yang, Wei-Min Chung, Lumin Chen, Yen-Pin Ho, Yao-Ching Hung, Wen-Lung Ma
This study identifies LDLR-mediated lipidome-transcriptome reprogramming as a mechanism for cisplatin insensitivity in ovarian cancer and demonstrates a lipid-based drug delivery strategy to enhance chemotherapy efficacy.
bioRxiv · Dec 21, 2018 · PreprintCancer Biology