Presenilin 1 (PS1) located at mitochondrial inner membrane regulates mitochondrial cristae junction proteins arrangement and cristae formation in HEK293 cells
Pan You, Pengjin Zhu, Hui Yu, Luwen Wang, Bo Su
This study shows PS1 localizes to mitochondrial inner membrane and regulates cristae structure by modulating protein interactions at cristae junctions, leading to mitochondrial dysfunction in Alzheimer's disease.
bioRxiv · Mar 8, 2026 · PreprintCell Biology