SEEKER: A genome-scale library-on-library screening platform for deciphering T cell recognition of antigen
Sicheng Li, Li Lin, Wenxu Wu, Binwen Liu, Huihui Ji, Zongyu Guo, Yaqiong Liu, Jing Wu, Bo Liu, Lisang Zhong, Xiaowo Wang, Huji Xu, Hai Qi
SEEKER screens TCR-pMHC combinations to identify antigen recognition, finding polyreactive T cells recognizing up to 80 autoantigens in autoimmune disease.
bioRxiv · Oct 3, 2026 · PreprintImmunology