Author

I. Cvijovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

M. M. Desai· 2 shared S. R. Quake· 2 shared A. M. Phillips· 1 shared A. M. Walczak· 1 shared A. Moulana· 1 shared B. H. Good· 1 shared E. R. Jerison· 1 shared J. Chang· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersEvolutionary Biology

M. M. Desai

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Author profile →

4 papers

Recent·Most cited

Long-term B cell memory emerges at uniform relative rates in the human immune response

I. Cvijovic, M. Swift, S. R. Quake

The paper analyzes single B cell data from human tissues to show lineage co-localization and uniform differentiation rates, providing a model for antibody memory formation.

bioRxiv · Nov 27, 2023Immunology

Reference-Free Germline Immunoglobulin Allele Discovery from B CellReceptor Sequencing Data

I. Cvijovic, E. R. Jerison, S. R. Quake

This paper introduces grmlin, a reference-free method to detect germline immunoglobulin alleles from B cell receptor sequencing data, achieving better specificity than existing methods.

bioRxiv · Nov 25, 2023 · PreprintImmunology

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

A. M. Phillips, K. R. Lawrence, A. Moulana, T. Dupic, J. Chang, M. S. Johnson, I. Cvijovic, T. Mora, A. M. Walczak, M. M. Desai

This study measures binding affinity landscapes of two influenza bnAbs to understand their evolutionary pathways and how they acquire breadth.

bioRxiv · May 25, 2021Evolutionary Biology

The effect of strong purifying selection on genetic diversity

I. Cvijovic, B. H. Good, M. M. Desai

This study analyzes the dynamics of neutral and deleterious mutations under strong purifying selection using a forward-time approach, revealing distortions in the site frequency spectrum that can mimic population expansions or positive selection.

bioRxiv · Oct 30, 2017Evolutionary Biology