Author

I. Doykov

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Hughes· 1 shared B. R. Thomas· 1 shared E. A. O'Toole· 1 shared K. Mills· 1 shared L. E. Coppock· 1 shared P. Dewan· 1 shared R. F. O'Shaughnessy· 1 shared T. Tachie-Menson· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperCell Biology

A. J. Hughes

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1 paper

Recent·Most cited

Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema

A. J. Hughes, L. E. Coppock, T. Tachie-Menson, B. R. Thomas, P. Dewan, I. Doykov, K. Mills, E. A. O'Toole, R. F. O'Shaughnessy

This study identifies dysregulated BMP and ERK1/2/AKT signaling in FLG-deficient keratinocytes and AE biopsies, linking FLG loss to altered desmosomal proteins and suggesting a SMAD1/Filaggrin/AKT therapeutic target.

bioRxiv · Mar 11, 2024 · PreprintCell Biology